Hello James,
Please tell us the version & build of DW that you are working on? [Help > About Dreamweaver]
I'm suspecting that Bootstrap is not the problem here, since it works fine on Win machines with way lower configurations than yours.
Are you saving the files on the local HDD or on a shared/remote network drive? Are you including any other external scripts etc along with the Bootstrap files?
Maybe you can just pass me one of the test files at subbaner@adobe.com& I'll take a look at it.
Thanks,
Subhadeep